1. Cancer Immunology

- Discovery of target for cancer immunotherapy

- Preclinical and biomarker research for immunotherapy candidates

- Mechanism of immunotherapy in syngeneic tumor models

2. Immune Cell therapy

- Autologous human primary immune cell therapy

- Non-viral gene editing of primary immune cells by crispr/cas9

1. Wu T, et al. (2020) Peripheral T cell expansion predicts tumour infiltration and clinical response. Nature. 579:274-78

2. Hernandez S, et al. (2018) The kinase activity of Hematopoietic Progenitor Kinase 1 is essential for the regulation of T cell function. Cell Rep. 25:80-94

3. Cho S, Lee HM, et al. (2018) Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat. Commun. 9:2757 (co-first author)

4. Cho S, et al. (2016) miR-23~27~24 clusters control effector T cell differentiation and function. J Exp Med. 213(2) 235-49

5. Lee HM, et al. (2015) IFNγ signaling endows DCs with the capacity to control type I inflammation during parasitic infection through promoting T-bet+ regulatory T cells. PLoS Pathog. 11(2) e1004635

6. Lee HM, et al. (2014) Progress and challenge of microRNA research in immunity. Front Genet. 5:178

7. Hsieh CS, et al. (2012) Thymic regulatory T cell selection. Nat. Rev. Immunol. 12:157-167

8. Lee HM, et al. (2012) A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self. Immunity 37:475-86

- Editorial Preview in Immunity 37:441-443

9. Porembka MR, et al. (2012) Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth. Cancer Immunol Immunother. 61:1373-85

10. Lee HM, et al. (2011) Thymic and peripheral differentiation of regulatory T cells. Adv. Immunol. 112:25-71

11. Ise W, et al. (2010) CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms. Nat. Immunol. 11:129-35

12. Lee HM and Hsieh CS. (2009) Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset. J. Immunol. 183:2261-2266

13. Graham DB, et al. (2007) An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells. J Exp Med. 204:2889-97

14. Hong E, et al. (2007) Structure of an atypical orphan response regulator protein supports a new phosphorylation-independent regulatory mechanism. J Biol Chem. 282: 20667-75

15. Lee HM, et al. (2006) Crystallization and preliminary X-ray crystallographic study of HP1043, a helicobacter pylori orphan response regulator. Biochim Biophys Acta. 1764: 989-91

16. Lee HM, et al. (2003) IL-4 augments anisomycin-induced p38 activation via Akt pathway in a follicular dendritic cell (FDC)-like line. FEBS Lett. 549: 110-114