<연구분야>
Cancer targeted drug delivery system
Photodynamic therapy using cancer targeted photosensitizers
Combination therapy for cancer treatment

<학술논문 (SCI(E))>
Koo N, Lee E, Chang J, Lee K, Chae Y. Pharmacokinetic landscape and interaction potential of SGLT2 inhibitors: Bridging in vitro findings and clinical implications. Pharmaceutics. 2025:17(12):1604.

Jang H, Chang J*. Strategic combinations of antibody–drug conjugates from 2023 to 2025: From dual therapies to innovative ADC-based regimens. Pharmaceutics. 2025:17(12):1581.

Song M, Yoon H, Yoon H, Lee H, Chae Y, Chang J*. Enhanced anticancer efficacy of photodynamic therapy in combination with immunotherapy. J Photochem Photobiol B. 2024:261:113048.

Hong G, Chang J*. Enhancing cancer treatment through combined approaches: photodynamic therapy in concert with other modalities. Pharmaceutics. 2024:16(11):1420.

Kang M, Kim M, Seol Y, Chang J, Lee K, Chae Y. Interactions of bosutinib with drug transporters: In vitro and In vivo inhibition of organic cation transporter 2, multidrug and toxin extrusion protein 1, and breast cancer resistance protein by bosutinib. Biomed Pharmacother. 2024:178:117114.

Gulnaz A, Chang J, Maeng H, Shin K, Lee K, Chae Y. A mechanism-based understanding of altered drug pharmacokinetics by gut microbiota. J Pharm Investig. 2023:53:73-92. (Co-First author)

Lee K, Chang J, Yoon J, Jin H, Chae Y. Findings on in vitro transporter-mediated drug interactions and their follow-up actions for labeling: analysis of drugs approved by US FDA between 2017 and 2021. Pharmaceutics. 2022:14(10):2078.

Lee H, Lee H, Chang J*. Inflammatory Cytokine: An Attractive Target for Cancer Treatment. Biomedicines. 2022:10(9):2116.

Rhew K, Chae Y, Chang J*. Progress and recent trends in photodynamic therapy with nanoparticles. J Pharm Investig. 2022:52(5):587-99.

Lee K, Chang J, Chae Y. Sensitive and valid assay for reliable evaluation of drug interactions mediated by human organic anion transporter 1 and 3 using 5？carboxyfuorescein. Anal Sci. 2022:38:1347-57. (Co-First author)

Jang I, Chang J, Kim J, Rhew K. Status of medications prescribed for psychiatric disorders in Korean pediatric and adolescent patients. Children. 2022:9(1):68.

Chae Y, Chang J, Lee M, Lim J, Shin K, Lee K. Regulation of drug transporters by microRNA and implications in disease treatment. J Pharm Investig. 2022:52:23-47.

Park J, Chang J*. Removal of chemical hazardous compounds using CATACOAT, a nano-platinum thermal catalyst system. J Environ Sci Health, Part A. 2021:56(14):1471-9.

Lee E, Kim H, Choi M, Chang J*. Crosstalk between autophagy and inflammatory processes in cancer. Life. 2021:11(9):903.

Choi M, Chae Y, Choi J, Chang J*. Potential therapeutic approaches through modulating the
autophagy process for skin barrier dysfunction. Int J Mol Sci. 2021;22(15):7869.

Chang J, Lee H, Kim J, Rhew K. Prevalence of anemia in pediatric patients according to asthma control: propensity score analysis. J Asthma and Allergy. 2021:14:743-51.

Chang J, Choi M. A molecular perspective on the potential benefits of metformin for the treatment of inflammatory skin disorders. Int J Mol Sci. 2020;21(23):8960.

Choi Y, Chang J, Jheon S, Han S, Kim J. Enhanced production of reactive oxygen species in HeLa cells under concurrent low-dose carboplatin and Photofrin® photodynamic therapy. Oncol Rep. 2018;40(1):339-45.

Chang J, Liu Y, Lee T, Lee W, Yoon I, Kim K. Tumor Size-Dependent Anticancer Efficacy of
Chlorin Derivatives for Photodynamic Therapy. Int J Mol Sci. 2018;19(6):1596.

Chang J, Lee D, Ban S, Oh J, Jung M, Kim S, Park S, Persaud K, Jheon S. Analysis of volatile organic compounds in exhaled breath for lung cancer diagnosis using a sensor system. Sens Actuators B Chem. 2018;255:800-7.

Chang J, Kim H, Jheon S, Lim C. Protective effects of GV1001 on myocardial ischemia-reperfusion injury. Mol Med Rep. 2017;16:7315-20.

Yi E, Han S, Chang J, Kim H, Kim J, Seo S, Chung J, Jheon S. Synchrotron tomographic images from human lung adenocarcinoma: Three-dimensional reconstruction and histologic correlations. Microsc Res Tech. 2017;80:1141-8.

Park C, Kim Y, Lee J, Lim H, Chang J, Jeong S, Kwon N. Anticalcification effect of a combination of decellularization, organic solvents and amino acid detoxification on glutaraldehyde-fixed xenopericardial heart valves in a large-animal long-term circulatory model. Interact Cardio Vasc Thorac Surg. 2017;25:391-9.

Yi E, Chang J, Leem C, Jeon C, Jheon S. Association of MAGE A1-6 expression with lung
cancer progression. J Cancer. 2017;8:1324-9. (Co-First author)

Jee H, Chang J, Yang E. Positive prehabilitative effect of intense treadmill exercise for ameliorating cancer cachexia symptoms in a mouse model. J Cancer. 2016;7:2378-87.

Chang J, Cho H, Jheon S. Anticancer efficacy of photodynamic therapy with lung cancer-targeted nanoparticles. J Vis Exp. 2016;118:e54865.

Chang J, Kim H, Yi E, Jheon S, Kim K. Reduction of ischaemia-reperfusion injury in a rat lung transplantation model by low-concentration GV1001. Eur J Cardiothorac Surg. 2016;50:972-9.

Chang J, Cho H, Yi E, Kim D, Jheon S. Hypocrellin B and paclitaxel-encapsulated hyaluronic acid-ceramide nanoparticles for targeted photodynamic therapy in lung cancer. J Photochem Photobiol, B. 2016;158:113-21.

Yi E, Chang J, Leem C, Kim S, Jheon S. Clinical results of photodynamic therapy in tracheobronchial malignancy. J Photochem Photobiol, B. 2015;156:56-60.

Chang J, Oak C, Sung N, Jheon S. The potential application of photodynamic therapy in drug-resistant tuberculosis. J Photochem Photobiol, B. 2015;150:60-5.

Yi E, Yang C, Leem C, Park Y, Chang J, Cho S, Jheon S. Clinical outcome of Photodynamic therapy in Esophageal squamous cell carcinoma. J Photochem Photobiol, B. 2014;141:20-5.

Chang J, Yoon I, Sun P, Yi E, Jheon S, Shim C. Anticancer efficacy of photodynamic therapy with hematoporphyrin-modified, doxorubicin-loaded nanoparticles in liver cancer. J Photochem Photobiol, B. 2014;140:49-56.

Maeng H, Lee W, Jin Q, Chang J, Shim W. Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway. Eur J Pharm Sci. 2014;62:189-96.

Kwak E, Shim W, Chang J, Chong S, Kim D, Chung S, Shim C. Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters. Xenobiotica. 2012;42(7):603-13.

Chang J, Shim W, Yang S, Kwak E, Chong S, Kim D, Chung S, Shim C. Liver cancer targeting of doxorubicin with reduced distribution to the heart using hematoporphyrin-modified albumin nanoparticles in rats. Pharm Res. 2012;29:795-805.

Yang S, Chang J, Shin B, Park S, Na K, Shim C. 99mTc-hematoporphyrin linked albumin nanoparticles for lung cancer targeted photodynamic therapy and imaging. J Mater Chem. 2010;20:904-6.