[연구분야]
Development of cancer therapeutics utilizing the theranostics
Development of senolytics

[국가연구과제 수행실적]
전이성 삼중음성유방암의 Trop2 표적 SMDCs (small molecule drug conjugates) 기반 신규 항암제 개발(한국연구재단-우수연구/세종과학펠로우십, 연구책임자, 2024. 05 – 2029. 04)

미토콘드리아 표적 신규항암제 개발(TIPS, 연구책임자, 2021. 11 – 2023. 10)

세포 카니발리즘 매개의 신규 암전이 극복 표적치료제 개발(한국연구재단-이공학문후속세대, 연구책임자, 2020. 05 – 2021. 07)

화학센서 기반의 신규 암 줄기세포 표적 저분자 치료제 개발 및 치료 기전 규명(한국연구재단-개인기초연구, 연구책임자, 2017. 05 – 2020. 02)

[학술논문]

Z. Wang, F. Zhang, B. Zhou, Y. Cui, L. Sun, M. Won, L. Xu, J. Sun, L. Wang, J. S. Kim, B. Dong, ‘BFO@Au leveraged membrane necrotherapy: Rapid tumor eradication via membrane oxidation and immune activation’ Biomaterials, 334, 124299, 2026.

M. Won*, C. Yoon, J. An, D. Kim, J. S. Kim, ‘Mitochondria-Targeted Antibiotics toward Drug Resistant TNBC’ ACS Appl. Bio Mater., 8, 7105-7112, 2025.

M. S. Levine, S. Sen, E. Y. Maier, M. Mota, M. Won, J. Li, J. F. Arambular, V. M. Lynch, J. S. Kim, R. A. DePinho, B. Iverson, J. L. Sessler, ‘Long-Lived Immunogenic Cell Death Induced by a Water-Soluble Redox Active Au(I) Bis-N-Heterocyclic Carbene’ J. Am. Chem. Soc., 147, 23574-23582, 2025.

Q. Zhou, Q. Ding, Z. Geng, C. Hu, L. Yang, Z. Kan, B. Dong, M. Won, H. Song, L. Xu, J. S. Kim, ‘A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing’ Nano-Micro Lett., 17, 50, 2025.

K Dou, J. Lu, Y. Xing, R. Wang, M. Won, J. Kim, F. Yu, J. S. Kim, ‘Metabolic Acidity/H2O2 Dual-Cascade-Activatable Molecular Imaging Platform Toward Metastatic Breast Tumor Malignancy’ Angew. Chem. Int. Ed., 64, e202419191, 2025.

S. Wang, Q. Wang, Y. Lv, Z. Liu, K. Lee, D. Kim, M. Won*, J. Shen, J. S. Kim, ‘Fluorescence imaging-guided lipid droplets-localized photodynamic therapy’ Aggregate, 6, e665, 2025.

N. Singh, M. Won*, J. An, C. Yoon, D. Kim, S. J. Lee, H. Kang, J. S. Kim, ‘Advances in covalent organic frameworks for cancer phototherapy’ Coord. Chem. Rev., 506, 215720, 2024.

W. Sun, J. Sun, Q. Ding, M. Qi, J. Zhou, Y. Shi, J. Liu, M. Won, X. Sun, X. Bai, B. Dong, J. S. Kim, L. Wang, ‘Breaking the Iron Homeostasis: Iron Capturing Nanocomposites for Combating Bacterial Biofilm’ Angew. Chem. Int. Ed., 63, e202319690, 2024.

N. Singh, M. Won*, Y. Xu, C. Yoon, J. Yoo, M. Li, H. Kang, J. S. Kim, ‘Covalent organic framework nanoparticles: Overcoming the challenges of hypoxia in cancer therapy’ Coord. Chem. Rev., 499, 215481, 2024.

L. Zheng, H. Zhang, M. Won, E. Kim, M. Li, J. S. Kim, ‘Codoping g-C3N4 with boron and graphene quantum dots: Enhancement of charge transfer for ultrasensitive and selective photoelectrochemical detection of dopamine’ Biosens. Bioelectron., 224, 115050, 2023.

H. S. Jung, S. Koo, M. Won*, S. An, H. Park, J. L. Sessler, J. Han, J. S. Kim, ‘Cu(II)-BODIPY photosensitizer for CAIX overexpressed cancer stem cell Therapy’ Chem. Sci., 14, 1808-1819, 2023.

X. Shi, M. Won*, C. Tang, Q. Ding, A. Sharma, F. Wang, J. S. Kim, ‘RNA splicing based on reporter genes system: Detection, imaging and applications’ Coord. Chem. Rev., 477, 214929, 2023.

M. Park, K. Sunwoo, Y.-J. Kim, M. Won, Y. Xu, Z. Pu, M. Li, J. Y. Kim, J. H. Seo, J. S. Kim, ‘Cutting Off H+ Leaks on Inner Mitochondrial Membrane: A Proton Modulation Approach to Selectively Eradicate Cancer Stem Cells’ J. Am. Chem. Soc., 145, 4647-4658. 2023.

J. An, H. Hong, M. Won, H. Rha, Q. Ding, N. Kang, H. Kang, J. S. Kim, ‘Mechanical stimuli-driven cancer therapeutics’ Chem. Soc. Rev., 52, 30-46, 2023.

S.-M. Jo, H. S. Kim, M. Won, C. Champanhac, J. S. Kim, F. R. Wurm, K. Landfester, ‘Dual-targeted Nanoreactors and Prodrugs: Hydrogen Peroxide triggers Oxidative Damages and Prodrug Activation for Synergistic Cancer Ablation’ Adv. Funct. Mater., 32, 220091, 2022.

H. Zhang, K. Li, L. Shi, X. Liu, M. Won, Y.-Z. Liu, Y. Choe, X.-Y. Liu, Y.-H. Liu, S.-Y. Chen, K.-K. Yu, J. S. Kim, X.-Q. Yu, ‘Discovery of Ultra-rapid/sensitive Lysosomal Fluorescence Lipophagy Process’ Angew. Chem. Int. Ed., 61, e2021164439, 2022.

S. Sen, M. Won, M. S. Levine, Y. Noh, A. C. Sedgwick, J. S. Kim, J. L. Sessler, J. F. Arambula, ‘Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future’ Chem. Soc. Rev., 51, 1212-1233, 2022.

M. Won*, J. H. Kim, M. S. Ji, J. S. Kim, ‘ROS activatable prodrug for ALDH overexpressed cancer stem cells’ Chem. Commun., 58, 72-75, 2022.

J. H. Kim, P. Verwilst, M. Won, J. Lee, J. L. Sessler, J. Han, J. S. Kim, ‘Functional Multi-component Agents That Target Cancer Stem Cells in Hypoxic Tumor Environments’ J. Am. Chem. Soc., 143, 14115–14124, 2021. (Front Cover)

S. Son, C. Zhang, M. Won, P. Jangili, M. Choi, J. Wu, J. S. Kim ‘Ultrasound activatable antiangiogenic sonosensitizer for VEGFR associated glioblastoma tumor models’ Aggregate, 2, e97, 2021. (Cover)

W. Y. Kim, M. Won*, S. Koo, X. Zhang, J. S. Kim ‘Mitochondrial H2Sn-Mediated Anti-Inflammatory Theranostics’ Nano-Micro Lett., 13, 168, 2021. (Front Cover)

S. Wang, W. X. Ren, J.-T. Hou, M. Won, J. An, Z. Chen, J. Shu, J. S. Kim, ‘Fluorescence imaging of pathophysiological microenvironments’ Chem. Soc. Rev., 50, 8887-8902, 2021.

S. Koo, M. Won*, H. Li, W. Y. Kim, M. Li, C. Yan, A. Sharma, Z. Guo, W.-H. Zhu, J. L. Sessler, J. Y. Lee, J. S. Kim, ‘Harnessing α-L-fucosidase for in vivo cellular senescence imaging’ Chem. Sci., 12, 10054-10062, 2021.

M. Won*, S. Koo, H. Li, J. L. Sessler, J. Y. Lee, A. Sharma, J. S. Kim, ‘An Ethacrynic Acid-Brominated BODIPY Photosensitizer (EA-BPS) Construct Enhances the Lethality of Reactive Oxygen Species in Hypoxic Tumor-Targeted Photodynamic Therapy’ Angew. Chem. Int. Ed., 60, 3196-3204, 2021.

J. Zhang, J. Kan, Y, Sun, M. Won, J. H. Kim, W. Zhang, J. Zhou, Z. Qian, J. S. Kim, ‘Nanoliposomal ratiometric fluorescent probe toward ONOO- flux’ ACS Appl. Bio Mater., 4, 2080-2088, 2021. (Cover)

M. Won*, M. Li, H. S. Kim, P. Liu, S. Koo, S. Son, J. H. Seo, J. S. Kim ‘Visible to mid IR: A library of multispectral diagnostic imaging’ Coord. Chem. Rev., 426, 213608, 2021.

J. Han, M. Won*, J. H. Kim, E. Jung, J. Paramesh, K. Min, J. S. Kim, ‘Cancer Stem Cell-targeted Bio imaging and Chemotherapeutic Perspective’ Chem. Soc. Rev., 49, 7856-7878, 2020 (Front Cover).

J. Zhou, P. Jangili, S. Son, M. S. Ji, M. Won, J. S. Kim, ‘Fluorescent Diagnostic Probes in Neurodegenerative Diseases’ Adv. Mater., 32, 2001945, 2020 (Front Cover)

C. Liu, H. S. Kim, M. Won*, E. Jung, J. S. Kim, ‘Navigating 2D Monoelemental Materials (Xenes) for Cancer Nanomedicine’ Matter (Cell Press), 3, 12-13, 2020.

K. Sunwoo, M. Won*, K-P. Ko, S-G. Chi, P. Verwilst, J. S. Kim, ‘Mitochondrial relocation of a common synthetic antibiotic: A non-genotoxic Approach to cancer therapy’ Chem (Cell Press), 6, 1408-1419, 2020.

J. H. Joo, M. Won, K. Park, D.-S. Shin, J. S. Kim, M. H. Lee, ‘A dicyanocoumarin-fused quinolinium based probe for NAD(P)H and its use for detecting glycolysis and hypoxia in living cells and tumor spheroids’ Sens. Actuators B: Chem., 320, 128360, 2020.

P. Liu, W. Fu, P. Verwilst, M. Won, J. Shin, Z. Cai, B. Tong, J. Shi, Y. Dong, J. S. Kim, ‘MDM2-Associated Clusterization-Triggered Emission and Apoptosis Induction Effectuated by a Theranostic Spiropolymer’ Angew. Chem. Int. Ed., 59, 8435-8439, 2020.

S. Y. Park, M. Won*, J. S. Kim, M. H. Lee, ‘Ratiometric fluorescent probe for monitoring tyrosinase activity in melanosomes of melanoma cancer cells’ Sens. Actuators B: Chem., 319, 128306, 2020.

W. Y. Kim, M. Won*, A. Salimi, A. Sharma, J. Lim, S-H. Kwon, J-Y. Jeon, J. Y. Lee, J. S. Kim, ‘Monoamine Oxidase-A Targeting Two Photon Probe for Prostate Tumor and Metastasis Imaging’ Chem. Commum., 55, 13267, 2019.

Sharma, M-G. Lee, M. Won, S. Koo, J. F. Arambula, J. L. Sessler, S-G. Chi, J. S. Kim, ‘Targeting Heterogenous Tumors Using a Multifunctional Molecular Prodrug’ J. Am. Chem. Soc., 141, 15611-15618, 2019 (Front Cover).

S. Koo, K. N. Bobba, H. S. Park, M. Y. Cho, M. Won, N. Valusamy, K. S. Hong, S. Bhuniya, J. S. Kim, ‘Molecular Theranostic Agent with Programmed Activation for Hypoxic Tumor’ ACS Appl. Bio Mater., 2, 4648-4655, 2019.

Y. Wang, M. Qiu, M. Won, E. Jung, T. Fan, N. Xie, S-G. Chi, H. Zhang, J. S. Kim, ‘Emerging 2D material-based nanocarrier for cancer therapy beyond graphene’ Coord. Chem. Rev., 400, 213041, 2019.

M. Won*, Y. Luo, D.H. Lee, E. Shin, D.S. Suh, T.H. Kim, H. Jin, J. Bae, ‘BAX is an essential key mediator of AP5M1-induced apoptosis in cervical carcinoma cells’ Biochem. Biophys. Res. Commun., 15, 368−373, 2019.

P. Jangili, M. Won, S. J. Kim, J. Chun, I. Shim, C. Kang, W. X. Ren, and J. S. Kim, ‘Binary drug reinforced first small molecule-based prodrug for synergistic anti-cancer effect’ ACS Appl. Bio Mater., 2, 3532−3539, 2019.

C. Duan, M. Won*, P. Verwilst, J. Xu, H. S. Kim, L. Zeng, J. S. Kim, ‘In vivo imaging of endogenously produced HClO in zebrafish and mice using a bright, photostable ratiometric fluorescent probe’ Anal. Chem., 91, 4172-4178, 2019.

N. Y. Lim, J. Ahn, M. Won*, W. Choi, J. S. Kim, J. H. Jung, ‘Novel Cyanostilbene-Based Fluorescent Probe for Hydroxyl Radicals and Its Two-Photon Bioimaging in Living Cells’ ACS Appl. Bio Mater., 2, 936-642, 2019.

S. Son, M. Won*, O. Green, N. Hananya, A. Sharma, Y. Jeon, J. H. Kwak, J. L. Sessler, D. Shabat, J. S. Kim, ‘Chemiluminescent Probe for the In Vitro and In Vivo Imaging of Cancers Over-expressing NQO1’ Angew. Chem. Int. Ed., 58, 1739-1743, 2019.

S. Y. Park, M. Won*, C. Kang, J. S. Kim, M. H. Lee, ‘A coumarin-naphthalimide hybrid as a ratiometric fluorescent probe for hNQO1’ Dyes Pigment., 164, 341-345, 2019.

N. H. Kim, M. Won*, J. S. Kim, Y. Huh, D. Kim, ‘A Highly Sensitive and Fast Responsive Fluorescent Probe for Detection of Gold(III) Ions based on the AIEgen Disaggregation’ Dyes Pigment., 160, 647-653, 2019.

M. Qiu, W. Ren, T. Jung, M. Won, G. Y. Park, D. K. Sang, L.-P. Liu, H. Zhang, J. S. Kim, ‘Omnipotent Phosphorene: Next Generation Two-Dimensional Nanoplatform for Multidisciplinary Biomedical Applications’ Chem. Soc. Rev., 47, 5588-5601, 2018.

S. A. Yoon, W. Kim, A. Sharma, P. Verwilst, M. Won, M. H. Lee, ‘A Fluorescent Cy7-Mercaptopyridine for the Selective Detection of Glutathione over Homocysteine and Cysteine’ Sensors, 18, 2897-2908, 2018.

Y. Zhou, M. Maiti, A. Sharma, M. Won, L. Yu, L. X. Miao, J. Shin, A. Podder, K.N. Bobba, J. Han, S. Bhuniya, J. S. Kim, ‘Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy’ J. Control. Release, 28, 14-22, 2018.

Podder, M. Won*, S. Kim, P. Verwilst, M. Maiti, Z. Yang, J. Qu, S. Bhuniya, J. S. Kim, ‘A two-photon fluorescent probe records the intracellular pH through ‘OR’ logic operation via internal calibration’ Sens. Actuators B: Chem., 268, 195-204, 2018.

Sharma, M.-G. Lee, H. Shi, M. Won, J. F. Arambula, J. L. Sessler, J. Y. Lee, S.-G. Chi, J. S. Kim, ‘Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug’ Chem (Cell Press), 4, 2370-2383, 2018.

H. S. Kim., T. Park, W. X. Ren, J.-Y Lim, M. Won, J. S. Heo, S. G. Lee, and J. S. Kim, ‘COX-2 targeting indomethacin conjugated fluorescent probe’ Dyes Pigment., 150, 261-266, 2018.

K. N. Bobba, M. Won*, I. Shim, N. Velusamy, Z. Yang, Junle Qu, J. S. Kim, S. Bhuniya, ‘BODIPY based Two Photon Fluorescent Probe Validates Tyrosinase Activity in Live Cells’ Chem. Commun., 53, 11213-11216, 2017.

H. Jin, M. Won*, E. Shin, H. M. Kim, K. Lee, J. Bae, ‘EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells’ Biochem. Biophys. Res. Commun., 482(2), 877-882, 2017.

H. Jin, M. Won*, S. E. Park, S. Lee, M. Park, J. Bae, ‘FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells’ PLoS One, 11(7), e0159112, 2016.

S. M. Ryou, J. H. Yeom, H. J. Kang, M. Won, J. S. Kim, B. Lee, M. J. Seong, N. C. Ha, J. Bae, K. Lee, ‘Gold nanoparticle-DNA aptamer composites as a universal carrier for in vivo delivery of biologically functional proteins’ J. Control. Release, 196, 287-380, 2014.

J. H. Yeom, S. M. Ryou, M. Won, M. Park, J. Bae, K. Lee, ‘Inhibition of Xenograft tumor growth by gold nanoparticle-DNA oligonucleotide conjugates-assisted delivery of BAX mRNA’ PLoS One, 8(9), e75369, 2013.

J. Bae, M. Won, D. Y. Kim, J. H. Kim, Y. M. Kim, Y. T. Kim, J. H. Nam, D. S. Suh, ‘Identification of differentially expressed microRNAs in endometrial cancer cells after progesterone treatment’ Int. J. Gynecol. Cancer, 22(4), 561-565, 2012.

S. Lee, T. H. Kim, M. Won, J. J. Ko, J. Rho, K. Lee, J. Bae, ‘Absence of a FOXL2 mutation (402C→G) in the blood of adult-type granulosa cell tumor patients possessing the FOXL2 mutation’ Int. J. Gynecol. Cancer, 20(8), 1341-1343, 2010.

D. H. Choi, W. S. Lee, M. Won, M. Park, H. O. Park, E. Kim, K. A. Lee, J. Bae, ‘The apolipoprotein A-I level is downregulated in the granulosa cells of patients with polycystic ovary syndrome and affects steroidogenesis’ J. Proteome Res., 9(9), 4329-4364, 2010.

M. Park, E. Shin, M. Won, J. H. Kim, H. Go, H. L. Kim, J. J. Ko, K. Lee, J. Bae, ‘FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells’ Mol. Endocrinol., 24(5) 1024-1059, 2010.

S. Yoon, H. J. Ha, Y. H. Kim, M. Won, M. Park, J. J. Ko, K. Lee, J. Bae, ‘IEX-1-induced cell death requires BIM and is modulated by MCL-1’ Biochem. Biophys. Res. Commun., 382(2), 400-403, 2009.

J. H. Kim, S. Yoon, M. Won, S. H. Sim, J. J. Ko, S. Han, K. A. Lee, K. Lee, J. Bae, ‘HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death’ Cell Physiol. Biochem., 23(13), 43-52, 2009.

J. Han, M. Park, J. H. Kim, A. Kim, M. Won, D. R. Lee, J. J. Ko, H. Yoon, S. H. Sim, K. Lee, J. Bae, ‘Increased expression of the testicular estrogen receptor alpha in adult mice exposed to low doses of methiocarb’ J. Appl. Toxicol., 29(5), 446-496, 2009.

E. Shin, H. Go, J. H. Yeom, M. Won, J. Bae, S. H. Han, K. Han, Y. Lee, N. C. Ha, C. J. Moore, B. Sohlberg, S. N. Cohen, K. Lee, ‘Identification of amino acid residues in the catalytic domain of RNase E essential for survival of Escherichia coli: functional analysis of DNase I subdomain’ Genetics, 179(4), 1871-1879, 2008.

M. Won*, S. Lee, S. Kim, S. Yoon, J. J. Ko, K. Lee, J. Bae, ‘Apoptosis of the mitochondria protein p32 (gc1qbp) in human ovarian cancer cells’ Korean J. Obes. & Gynecol., 51(8), 858-865, 2008.

Y. Kang, D. C. Lee, J. Han, S. Yoon, M. Won, J. H. Yeom, M. J. Seong, J. J. Ko, K. A. Lee, K. Lee, J. Bae, ‘NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling’ Biochem. Biophys. Res. Commun., 359(1), 76-82, 2007.

[특허]
Mitochondrial target-repurposed antibiotics for non-nuclear genotoxic chemotherapy and pharmaceutical composition for anti-cancer containing the same (10-2023-0182550), Korea, 2023.

Mitochondrial hydrogen polysulfide responsive theragnostic agent for anti-inflammation therapy (10-2022-0093661), Korea, 2022.

A tumor-targeted sonodynamic therapeutics (10-2022-0080011), Korea, 2022.

Anticancer prodrug for targeting heterogeneous tumor cells (10-2434349), Korea, 2022.

Antibiotic modified anticancer compounds for the treatment of non-genetic anti-cancer and anticancer pharmaceutical composition comprising the same (10-2362023), Korea, 2022.

α-L-fucosidase-reactive fluorescent probe compound and method of detecting senescence using the same (10-2675585), Korea, 2022.

A tumor-targeted Photodynamic therapeutic compound (10-2691023), Korea, 2021.

Repurposed antibiotics for non-nuclear genotoxic chemotherapy and pharmaceutical composition for anti-cancer containing the same (PCT/KR2020/003248), PCT, 2020.

Chemiluminescent probe compound for detecting cancer cell and a cancer cell detection chemiluminescent sensor comprising the same (10-2332454), Korea, 2019.

Anti-cancer prodrug for overcoming multidrug resistance (10-2326738), Korea, 2019.

ANTICANCER PRODRUG FOR OVERCOMING DRUG RESISTANCE (16/547,726), U.S.A, 2019.

Repurposed antibiotics for non-nuclear genotoxic chemotherapy and pharmaceutical composition for anti-cancer containing the same (10-2246180), Korea, 2019.

Anti-cancer prodrug for overcoming drug resistance (10-2105938), Korea, 2018.

Fluorescent probe compound for detecting cancer cell and a cancer cell detection fluorescence sensor comprising the same (10-2105937), Korea, 2018.

Fluorescent probe compound for detecting tyrosinase in live cells and a tyrosinase detection fluorescence sensor comprising the same (10-2105939), Korea, 2018.

Pharmaceutical composition comprising tumor suppressor AP5M1 for enhancing anti-cancer effect for cervical cancer (10-1618518), Korea, 2015.

Analytical methods or kit for diagnosing polycystic ovary syndrome (10-1142779), Korea, 2009.